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The Single Substitution I259T, Conserved in the Plasminogen Activator Pla of Pandemic Yersinia pestis Branches, Enhances Fibrinolytic Activity

The outer membrane plasminogen activator Pla of Yersinia pestis is a central virulence factor in plague. The primary structure of the Pla β-barrel is conserved in Y. pestis biovars Antiqua, Medievalis, and Orientalis, which are associated with pandemics of plague. The Pla molecule of the ancestral Y...

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Main Authors: Haiko, Johanna, Kukkonen, Maini, Ravantti, Janne J., Westerlund-Wikström, Benita, Korhonen, Timo K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715710/
https://ncbi.nlm.nih.gov/pubmed/19465664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00489-09
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