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CD8 T Cells in Old Mice Contribute to the Innate Immune Response to Mycobacterium tuberculosis via Interleukin-12p70-Dependent and Antigen-Independent Production of Gamma Interferon

Elderly individuals have increased morbidity and mortality associated with infectious diseases due in part to the progressive age-associated decline in immune function. Despite this, the old mouse model of Mycobacterium tuberculosis infection has revealed a CD8- and gamma interferon (IFN-γ)-dependen...

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Detalhes bibliográficos
Main Authors: Vesosky, Bridget, Rottinghaus, Erin K., Davis, Craig, Turner, Joanne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715662/
https://ncbi.nlm.nih.gov/pubmed/19470747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00295-09
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