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Reintroduction of Two Deleted Virulence Loci Restores Full Virulence to the Live Vaccine Strain of Francisella tularensis

A disadvantage of several old vaccines is that the genetic events resulting in the attenuation are often largely unknown and reversion to virulence cannot be excluded. In the 1950s, a live vaccine strain, LVS, was developed from a type B strain of Francisella tularensis, the causative agent of tular...

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Detalhes bibliográficos
Main Authors: Salomonsson, Emelie, Kuoppa, Kerstin, Forslund, Anna-Lena, Zingmark, Carl, Golovliov, Igor, Sjöstedt, Anders, Noppa, Laila, Forsberg, Åke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715654/
https://ncbi.nlm.nih.gov/pubmed/19506014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00196-09
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