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Cytochrome P450 3A Inhibition by Atazanavir and Ritonavir, but Not Demography or Drug Formulation, Influences Saquinavir Population Pharmacokinetics in Human Immunodeficiency Virus Type 1-Infected Adults

Inadequate concentrations of the human immunodeficiency virus (HIV) protease inhibitor saquinavir jeopardize individual therapy success or produce side effects despite treatment according to the current guidelines. We performed a population pharmacokinetic analysis with NONMEM and determined that th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: von Hentig, Nils, Lötsch, Jörn
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715593/
https://ncbi.nlm.nih.gov/pubmed/19528289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00025-09
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