Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam

Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaqui...

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Autori principali: Nguyen, Dao Van Hoang, Nguyen, Quoc Phuc, Nguyen, Ngoa Dang, Le, Thuy Thi Thanh, Nguyen, The Duy, Dinh, Duy Ngoc, Nguyen, Thanh Xuan, Bui, Dai, Chavchich, Marina, Edstein, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715592/
https://ncbi.nlm.nih.gov/pubmed/19528277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01717-08
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