An Essential Role for Non–Bone Marrow–Derived Cells in Control of Pseudomonas aeruginosa Pneumonia

MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expresses ligands for multiple TLRs. MyD88(−/−) (KO) mice are highly susceptible to aerosolized P. aeruginosa, failing to elicit an early inflammatory res...

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Bibliographic Details
Main Authors: Hajjar, Adeline M., Harowicz, Heidi, Liggitt, H. Denny, Fink, Pamela J., Wilson, Christopher B., Skerrett, Shawn J.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715354/
https://ncbi.nlm.nih.gov/pubmed/16100080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0199OC
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