Regulation and localization of tyrosine(216) phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration

Inactivation of glycogen synthase kinase-3β (GSK3β) by S(9) phosphorylation is implicated in mechanisms of neuronal survival. Phosphorylation of a distinct site, Y(216), on GSK3β is necessary for its activity; however, whether this site can be regulated in cells is unknown. Therefore we examined the...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bhat, Ratan V., Shanley, Jason, Correll, Maryann P., Fieles, William E., Keith, Richard A., Scott, Clay W., Lee, Chi-Ming
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27150/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995469/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190297597
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