Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity

Ion flow into the rod photoreceptor outer segment (ROS) is regulated by a member of the cyclic-nucleotide-gated cation-channel family; this channel consists of two subunit types, α and β. In the rod cells, the Cngb1 locus encodes the channel β-subunit and two related glutamic-acid-rich proteins (GAR...

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Detalhes bibliográficos
Main Authors: Zhang, Youwen, Molday, Laurie L., Molday, Robert S., Sarfare, Shanta S., Woodruff, Michael L., Fain, Gordon L., Kraft, Timothy W., Pittler, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714441/
https://ncbi.nlm.nih.gov/pubmed/19339551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.042531
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