Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction

Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT) and stavudine (d4T), cause toxicities to numerous tissues, including the liver and vasculature. While much is known about hepatic NRTI toxicity, the mechanism of toxicity in endothelial cells is incompletely understood. Hu...

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Bibliografiske detaljer
Main Authors: Kline, Erik R., Bassit, Leda, Hernandez-Santiago, Brenda I., Detorio, Mervi A., Liang, Bill, Kleinhenz, Dean J., Walp, Erik R., Dikalov, Sergey, Jones, Dean P., Schinazi, Raymond F., Sutliff, Roy L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714048/
https://ncbi.nlm.nih.gov/pubmed/19067249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-008-9029-8
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