Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

Severe acute respiratory syndrome (SARS) coronavirus is highly pathogenic in humans and evades innate immunity at multiple levels. It has evolved various strategies to counteract the production and action of type I interferons, which mobilize the front-line defense against viral infection. In this s...

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Bibliographische Detailangaben
Hauptverfasser: Siu, Kam-Leung, Kok, Kin-Hang, Ng, Ming-Him James, Poon, Vincent K. M., Yuen, Kwok-Yung, Zheng, Bo-Jian, Jin, Dong-Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713514/
https://ncbi.nlm.nih.gov/pubmed/19380580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008227
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