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Development and validation of a fluorogenic assay to measure Separase enzyme activity
Separase, an endopeptidase, plays a pivotal role in the separation of sister chromatids at anaphase by cleaving its substrate cohesin Rad21. Recent study suggests that Separase is an oncogene. Overexpression of Separase induces aneuploidy and mammary tumorigenesis in mice (Zhang et al., 2008, PNAS 1...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713383/ https://ncbi.nlm.nih.gov/pubmed/19497291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.05.046 |
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