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Development and validation of a fluorogenic assay to measure Separase enzyme activity
Separase, an endopeptidase, plays a pivotal role in the separation of sister chromatids at anaphase by cleaving its substrate cohesin Rad21. Recent study suggests that Separase is an oncogene. Overexpression of Separase induces aneuploidy and mammary tumorigenesis in mice (Zhang et al., 2008, PNAS 1...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713383/ https://ncbi.nlm.nih.gov/pubmed/19497291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.05.046 |
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