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MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway

Phenotypic remodeling of Schwann cells is required to ensure successful regeneration of damaged peripheral axons. After nerve damage, Schwann cells produce an over 100-fold increase in metalloproteinase-9 (MMP-9), and therapy with an MMP inhibitor increases the number of resident (but not infiltrati...

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Bibliografski detalji
Glavni autori: Chattopadhyay, Sharmila, Shubayev, Veronica I.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713381/
https://ncbi.nlm.nih.gov/pubmed/19229995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20851
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