Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

BACKGROUND: Due to the widespread abusage of antibiotics, antibiotic-resistance in Streptococcus pneumoniae (S. pneumoniae) has been increasing quickly in recent years, and it is obviously urgent to develop new types of antibiotics. Two-component systems (TCSs) are the major signal transduction path...

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Detalhes bibliográficos
Main Authors: Li, Nan, Wang, Fei, Niu, Siqiang, Cao, Ju, Wu, Kaifeng, Li, Youqiang, Yin, Nanlin, Zhang, Xuemei, Zhu, Weiliang, Yin, Yibing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713251/
https://ncbi.nlm.nih.gov/pubmed/19558698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-129
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