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Eosinophil-Selective Binding and Proapoptotic Effect in Vitro of a Synthetic Siglec-8 Ligand, Polymeric 6′-Sulfated Sialyl Lewis X
The lectin Siglec-8 (sialic acid-binding, immunoglobulin-like lectin), which is selectively expressed on eosinophil surfaces and regulates eosinophil survival, preferentially binds to the glycan 6′-sulfo-sialyl Lewis X (6′-sulfo-sLe(x)). Antibody engagement of Siglec-8 on eosinophils causes their ap...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713093/ https://ncbi.nlm.nih.gov/pubmed/19458105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152439 |
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