The binding of Thioflavin-T and its neutral analog BTA-1 to protofibrils of the Alzheimer Aβ(16-22) peptide probed by molecular dynamics simulations

Thioflavin T (ThT) is a fluorescent dye commonly used to stain amyloid plaques, however, the binding sites of this dye onto fibrils are poorly characterized. We present molecular dynamics simulations of the binding of ThT and its neutral analog BTA-1 to model protofibrils of the Alzheimer Amyloid Aβ...

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Main Authors: Wu, Chun, Wang, Zhixiang, Lei, Hongxing, Duan, Yong, Bowers, Michael T., Shea, Joan-Emma
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712570/
https://ncbi.nlm.nih.gov/pubmed/18851978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.062
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