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Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix

BACKGROUND: Deacetylation of histones plays a fundamental role in gene silencing, and this is mediated by a corepressor complex containing Sin3 as an essential scaffold protein. In this report we examine the evolution of two proteins in this complex, the Sin3-associated proteins SAP30L and SAP30, by...

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Autors principals: Viiri, Keijo M, Heinonen, Taisto YK, Mäki, Markku, Lohi, Olli
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711940/
https://ncbi.nlm.nih.gov/pubmed/19566944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-9-149
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