Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

BACKGROUND: In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an AT-II receptor antagonist. We now aimed to investigate the effect of treati...

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Bibliographic Details
Main Authors: Failli, Paola, Alfarano, Chiara, Franchi-Micheli, Sergio, Mannucci, Edoardo, Cerbai, Elisabetta, Mugelli, Alessandro, Raimondi, Laura
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711933/
https://ncbi.nlm.nih.gov/pubmed/19545435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-8-32
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