The trk Tyrosine Protein Kinase Mediates the Mitogenic Properties of Nerve Growth Factor and Neurotrophin-3

The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF). Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter S phase, grow in semisolid medium, and become morphologically transformed. These mitogenic effects are absolutely depende...

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Auteurs principaux: Cordon-Cardo, Carlos, Tapley, Peter, Jing, Shuqian, Nanduri, Venkata, O’Rourke, Edward, Lamballe, Fabienne, Kovary, Karla, Klein, Rüdiger, Jones, Kevin R., Reichardt, Louis F., Barbacid, Mariano
Format: Artigo
Langue:Inglês
Publié: 1991
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711891/
https://ncbi.nlm.nih.gov/pubmed/1649007
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