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IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation
IL-6 overexpression protects mice from hyperoxic acute lung injury in vivo, and treatment with IL-6 protects cells from oxidant-mediated death in vitro. The mechanisms of protection, however, are not clear. We characterized the expression, localization, and regulation of Bax, a proapoptotic member o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711806/ https://ncbi.nlm.nih.gov/pubmed/19376889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90381.2008 |
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