Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

Epidermal growth factor receptor (EGFR) signaling contributes to aortic valve development in mice. Because developmental phenotypes in Egfr-null mice are dependent on genetic background, the hypomorphic Egfr(wa2) allele was made congenic on C57BL/6J (B6) and 129S1/SvImJ (129) backgrounds and used to...

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Detalhes bibliográficos
Main Authors: Barrick, Cordelia J., Roberts, Reade B., Rojas, Mauricio, Rajamannan, Nalini M., Suitt, Carolyn B., O'Brien, Kevin D., Smyth, Susan S., Threadgill, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711734/
https://ncbi.nlm.nih.gov/pubmed/19448146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00866.2008
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