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Enhancement of I(h), but not inhibition of I(M), is a key mechanism underlying the PACAP-induced increase in excitability of guinea pig intrinsic cardiac neurons
Pituitary adenylate cyclase-activating polypeptide (PACAP) increases excitability of guinea pig cardiac neurons, an effect mediated by PACAP-selective PAC(1) receptors. In dissociated guinea pig cardiac neurons, PACAP causes a positive shift of the voltage dependence of activation of the hyperpolari...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711694/ https://ncbi.nlm.nih.gov/pubmed/19403861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00039.2009 |
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