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NMR Analysis of the Architecture and Functional Remodeling of a Modular Multi-Domain Protein, RPA.

[Image: see text] Modular proteins with multiple domains tethered by flexible linkers have variable global archiectures. Using the eukaryotic ssDNA binding protein, Replication Protein A (RPA), we demonstrate that NMR spectroscopy is a powerful tool to characterize the remodeling of architecture in...

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Detalhes bibliográficos
Main Authors: Brosey, Chris A., Chagot, Marie-Eve, Ehrhardt, Mark, Pretto, Dalyir I., Weiner, Brian E., Chazin, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711642/
https://ncbi.nlm.nih.gov/pubmed/19378948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9013634
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