Mechanisms of β-Adrenergic Modulation of I(Ks) in the Guinea-Pig Ventricle: Insights from Experimental and Model-Based Analysis

Detailed understanding of I(Ks) gating complexity may provide clues regarding the mechanisms of repolarization instability and the resulting arrhythmias. We developed and tested a kinetic model to interpret physiologically relevant I(Ks) properties, including pause-dependence and modulation by β-adr...

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Detalles Bibliográficos
Autores principales: Severi, Stefano, Corsi, Cristiana, Rocchetti, Marcella, Zaza, Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2009
Materias:
Electrophysiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711398/
https://ncbi.nlm.nih.gov/pubmed/19413992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.017
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