Antigen sensitivity is a major determinant of CD8(+) T-cell polyfunctionality and HIV-suppressive activity

CD8(+) T cells are major players in the immune response against HIV. However, recent failures in the development of T cell–based vaccines against HIV-1 have emphasized the need to reassess our basic knowledge of T cell–mediated efficacy. CD8(+) T cells from HIV-1–infected patients with slow disease...

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Detalhes bibliográficos
Main Authors: Almeida, Jorge R., Sauce, Delphine, Price, David A., Papagno, Laura, Shin, So Youn, Moris, Arnaud, Larsen, Martin, Pancino, Gianfranco, Douek, Daniel C., Autran, Brigitte, Sáez-Cirión, Asier, Appay, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710928/
https://ncbi.nlm.nih.gov/pubmed/19389882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206557
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