Potent Inhibitors of Huntingtin Protein Aggregation in a Cell-Based Assay

A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar po...

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Main Authors: Rinderspacher, Alison, Cremona, Maria Laura, Liu, Yidong, Deng, Shi-Xian, Xie, Yuli, Gong, Gangli, Aulner, Nathalie, Többen, Udo, Myers, Katherine, Chung, Caty, Andersen, Monique, Vidović, Dušica, Schürer, Stephan, Brandén, Lars, Yamamoto, Ai, Landry, Donald W.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710884/
https://ncbi.nlm.nih.gov/pubmed/19243939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.087
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