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Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: substrate triggering of O(2) addition but not flavin reduction

PvdA catalyzes the hydroxylation of the sidechain primary amine of ornithine in the initial step of the biosynthesis of the Pseudomonas aeruginosa siderophore pyoverdin. The reaction requires FAD, NADPH, and O(2). PvdA uses the same co-substrates as several flavin-dependent hydroxylases that differ...

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Autori principali: Meneely, Kathleen M., Barr, Eric W., Bollinger, J. Martin, Lamb, Audrey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710847/
https://ncbi.nlm.nih.gov/pubmed/19368334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900442z
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