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Oxidative Damage to the c-fos Gene and Reduction of Its Transcription After Focal Cerebral Ischemia

We investigated oxidative damage to the c-fos gene and to its transcription in the brain of Long—Evans rats using a transient focal cerebral ischemia and reperfusion (FCIR) model. We observed a significant (p < 0.001) increase in the immunoreactivity to 8-hydroxy-2′-guanine (oh8G) and its deoxy f...

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Autori principali: Cui, Jiankun, Holmes, Eric H., Liu, Philip K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709844/
https://ncbi.nlm.nih.gov/pubmed/10461908
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