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Costimulation Prevents Allograft Acceptance Induced by CD40-CD40L Blockade

Disrupting the CD40-CD40L costimulation pathway promotes allograft acceptance in many settings. Herein, we demonstrate that stimulating OX40 overrides cardiac allograft acceptance induced by disrupting CD40-CD40L interactions. This effect of OX40 stimulation was dependent upon CD4+ T cells, which in...

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Bibliografiske detaljer
Main Authors: Burrell, Bryna E., Lu, Guanyi, Li, Xian C., Bishop, D. Keith
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709759/
https://ncbi.nlm.nih.gov/pubmed/19109169
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