Calcimimetic Inhibits Late-Stage Cyst Growth in ADPKD

In polycystic kidney disease (PKD), genetic mutations in polycystin 1 and 2 lead to defective intracellular trafficking of calcium, thereby decreasing intracellular calcium and altering cAMP signaling to favor proliferation. We hypothesized that calcimimetics, allosteric modulators of the calcium-se...

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Autori principali: Gattone, Vincent H., Chen, Neal X., Sinders, Rachel M., Seifert, Mark F., Duan, Danxia, Martin, David, Henley, Charles, Moe, Sharon M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2009
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709677/
https://ncbi.nlm.nih.gov/pubmed/19423689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008090927
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