Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons

Treatment of degenerating basal forebrain cholinergic neurons with nerve growth factor (NGF) in Alzheimer’s disease has long been contemplated, but an effective and safe delivery method has been lacking. Towards achieving this goal, we are currently developing CERE-110, an adeno-associated virus-bas...

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Autori principali: Bishop, Kathie M., Hofer, Eva K., Mehta, Arpesh, Ramirez, Anthony, Sun, Liangwu, Tuszynski, Mark, Bartus, Raymond T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709503/
https://ncbi.nlm.nih.gov/pubmed/18439998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.03.004
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