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ZBTB2, a Novel Master Regulator of the p53 Pathway

We found that ZBTB2, a POK family transcription factor, is a potent repressor of the ARF-HDM2-p53-p21 pathway important in cell cycle regulation. ZBTB2 repressed transcription of the ARF, p53, and p21 genes, but activated the HDM2 gene. In particular, ZBTB2 repressed transcription of the p21 gene by...

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Detalhes bibliográficos
Main Authors: Jeon, Bu-Nam, Choi, Won-Il, Yu, Mi-Young, Yoon, A-Rum, Kim, Myung-Hwa, Yun, Chae-Ok, Hur, Man-Wook
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709380/
https://ncbi.nlm.nih.gov/pubmed/19380588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809559200
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