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Increased Efficiency of Case-Control Association Analysis by Using Allele-Sharing and Covariate Information
OBJECTIVE: We compared the efficiency of case selection strategies for following up a genome-wide linkage screen of multiplex families. We simulated datasets under three models by which continuous environmental or clinical covariates may contribute to disease risk or linkage heterogeneity: (i) a qua...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
S. Karger AG
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709298/ https://ncbi.nlm.nih.gov/pubmed/17934318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000109732 |
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