The Paradoxical Increase in Cortisol Secretion Induced by Dexamethasone in Primary Pigmented Nodular Adrenocortical Disease Involves a Glucocorticoid Receptor-Mediated Effect of Dexamethasone on Protein Kinase A Catalytic Subunits

Context: Primary pigmented nodular adrenocortical disease (PPNAD) results in most cases from mutations of the protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene. Patients with PPNAD exhibit a paradoxical increase in cortisol secretion in response to dexamethasone. Objective: The aim was to...

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Detalhes bibliográficos
Main Authors: Louiset, Estelle, Stratakis, Constantine A., Perraudin, Véronique, Griffin, Kurt J., Libé, Rossella, Cabrol, Sylvie, Fève, Bruno, Young, Jacques, Groussin, Lionel, Bertherat, Jérôme, Lefebvre, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708955/
https://ncbi.nlm.nih.gov/pubmed/19383776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2009-0031
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