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Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase from Mesorhizobium loti MAFF303099 and its Mechanistic Implications

A vitamin B(6) degradative pathway has recently been identified and characterized in Mesorhizobium loti MAFF303099. One of the enzymes on this pathway, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO), is a flavin-dependent enzyme and catalyzes the oxidative ring opening of 2-methyl-3-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McCulloch, Kathryn M., Mukherjee, Tathagata, Begley, Tadhg P., Ealick, Steven E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708785/
https://ncbi.nlm.nih.gov/pubmed/19317437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900149f
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