PTEN Deficiency in a Luminal ErbB-2 Mouse Model Results in Dramatic Acceleration of Mammary Tumorigenesis and Metastasis

Overexpression and/or amplification of the ErbB-2 oncogene as well as inactivation of the PTEN tumor suppressor are two important genetic events in human breast carcinogenesis. To address the biological impact of conditional inactivation of PTEN on ErbB-2-induced mammary tumorigenesis, we generated...

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Autors principals: Schade, Babette, Rao, Trisha, Dourdin, Nathalie, Lesurf, Robert, Hallett, Michael, Cardiff, Robert D., Muller, William J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707232/
https://ncbi.nlm.nih.gov/pubmed/19435886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018937
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