Skeletal Consequences of Deletion of Steroid Receptor Coactivator-2/Transcription Intermediary Factor-2

Both estrogen receptor (ER) and peroxisome proliferator-activated receptor γ (PPARγ) regulate bone metabolism, and because steroid receptor coactivator (SRC)-2 (TIF-2) enhances ER and PPARγ activity, we examined the consequences of deletion of SRC-2 on bone using SRC-2 knock out (KO) mice. Loss of S...

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Main Authors: Mödder, Ulrike I., Monroe, David G., Fraser, Daniel G., Spelsberg, Thomas C., Rosen, Clifford J., Géhin, Martine, Chambon, Pierre, O'Malley, Bert W., Khosla, Sundeep
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707192/
https://ncbi.nlm.nih.gov/pubmed/19423703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000836
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