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Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma

PURPOSE: Romidepsin is a potent histone deacetylase inhibitor under clinical development. The objective of this study was to evaluate the effect of demographic, clinical and pharmacogenetic covariates on the pharmacokinetics of romidepsin in patients with T-cell lymphoma. EXPERIMENTAL DESIGN: Pharma...

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Huvudupphovsmän: Woo, Sukyung, Gardner, Erin R., Chen, Xiaohong, Ockers, Sandra B., Baum, Caitlin E., Sissung, Tristan M., Price, Douglas K., Frye, Robin, Piekarz, Richard L., Bates, Susan E., Figg, William D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707030/
https://ncbi.nlm.nih.gov/pubmed/19228751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1215
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