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LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration cofactor role for these retroviruses is unclear. While a single integrase binding domain (IBD) binds integrase, a complex N-terminal domain ensemble (NDE) interacts with unknown chro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706977/ https://ncbi.nlm.nih.gov/pubmed/19609362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000522 |
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