Gene Conversion between the X Chromosome and the Male-Specific Region of the Y Chromosome at a Translocation Hotspot

Outside the pseudoautosomal regions, the mammalian sex chromosomes are thought to have been genetically isolated for up to 350 million years. However, in humans pathogenic XY translocations occur in XY-homologous (gametologous) regions, causing sex-reversal and infertility. Gene conversion might acc...

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Hlavní autoři: Rosser, Zoë H., Balaresque, Patricia, Jobling, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2009
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706966/
https://ncbi.nlm.nih.gov/pubmed/19576564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.06.009
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