Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder

We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wide association studies. This method corrects for linkage disequilibrium between SNPs, variable gene size, and multiple testing of nonindependent pathw...

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Hauptverfasser: Holmans, Peter, Green, Elaine K., Pahwa, Jaspreet Singh, Ferreira, Manuel A.R., Purcell, Shaun M., Sklar, Pamela, Owen, Michael J., O'Donovan, Michael C., Craddock, Nick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706963/
https://ncbi.nlm.nih.gov/pubmed/19539887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.05.011
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