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Structural and Mechanistic Studies of Mofegiline Inhibition of Recombinant Human Monoamine Oxidase B
Mechanistic and structural studies have been carried out to investigate the molecular basis for the irreversible inhibition of human MAO-B by mofegiline. Competitive inhibition with substrate shows an apparent K(i) of 28 nM. Irreversible inhibition of MAO-B occurs with a 1:1 molar stoichiometry with...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706497/ https://ncbi.nlm.nih.gov/pubmed/19053775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8011867 |
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