The EP4 receptor antagonist, L-161,982, blocks prostaglandin E(2)-induced Signal Transduction and Cell Proliferation in HCA-7 colon cancer cells

Accumulating evidence indicates that elevated levels of prostaglandin E(2) (PGE(2)) can increase intestinal epithelial cell proliferation, and thus play a role in colorectal tumorigenesis. PGE(2) exerts its effects through four G-protein coupled PGE receptor (EP) subtypes, named the EP1, EP2, EP3, a...

Full description

Saved in:
Bibliographic Details
Main Authors: Cherukuri, Durga Prasad, Chen, Xiao BO, Goulet, Anne-Christine, Young, Robert N, Han, Yongxin, Heimark, Ronald L, Regan, John W, Meuillet, Emmanuelle, Nelson, Mark A
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706013/
https://ncbi.nlm.nih.gov/pubmed/17631291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.06.004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items