Altered effector function of peripheral cytotoxic cells in COPD

BACKGROUND: There is mounting evidence that perforin and granzymes are important mediators in the lung destruction seen in COPD. We investigated the characteristics of the three main perforin and granzyme containing peripheral cells, namely CD8(+ )T lymphocytes, natural killer (NK; CD56(+)CD3(-)) ce...

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Detalhes bibliográficos
Main Authors: Urbanowicz, Richard A, Lamb, Jonathan R, Todd, Ian, Corne, Jonathan M, Fairclough, Lucy C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705911/
https://ncbi.nlm.nih.gov/pubmed/19545425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-53
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