High affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin

In fission yeast, assembly of centromeric heterochromatin requires the RITS complex, which consists of Ago1, Tas3, Chp1, and siRNAs derived from centromeric repeats. Recruitment of RITS to centromeres has been proposed to depend on siRNA-dependent targeting of Ago1 to centromeric sequences. Previous...

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Bibliographic Details
Main Authors: Schalch, Thomas, Job, Godwin, Noffsinger, Victoria J., Shanker, Sreenath, Kuscu, Canan, Joshua-Tor, Leemor, Partridge., Janet F.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705653/
https://ncbi.nlm.nih.gov/pubmed/19362535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.02.024
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