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Crystallization and preliminary crystallographic studies of the single-chain variable fragment of antibody chA21 in complex with an N-terminal fragment of ErbB2

ErbB2 is a transmembrane tyrosine kinase, the overexpression of which causes abnormality and disorder in cell signalling and leads to cell transformation. Previously, an anti-ErbB2 single-chain chimeric antibody chA21 that specifically inhibits the growth of ErbB2-overexpressing cancer cells in vitr...

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Detalhes bibliográficos
Main Authors: Liu, Yang, Zhou, Huihao, Zhu, Juanjuan, Gao, Yongxiang, Niu, Liwen, Liu, Jing, Teng, Maikun
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705636/
https://ncbi.nlm.nih.gov/pubmed/19574641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109020107
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