CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus dehydration, decreased mucus transport, and mucus plugging of the airways. CFTR is normally expressed in ciliated epithelia...

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Autors principals: Zhang, Liqun, Button, Brian, Gabriel, Sherif E., Burkett, Susan, Yan, Yu, Skiadopoulos, Mario H., Dang, Yan Li, Vogel, Leatrice N., McKay, Tristan, Mengos, April, Boucher, Richard C., Collins, Peter L., Pickles, Raymond J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705187/
https://ncbi.nlm.nih.gov/pubmed/19621064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000155
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