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Modeling the Repertoire of True Tumor-Specific MHC I Epitopes in a Human Tumor
DNA replication has a finite measurable error rate, net of repair, in all cells. Clonal proliferation of cancer cells leads therefore to accumulation of random mutations. A proportion of these mutational events can create new immunogenic epitopes that, if processed and presented by an MHC allele, ma...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704956/ https://ncbi.nlm.nih.gov/pubmed/19593447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006094 |
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