Genetic and Biochemical Characterization of the First Extended-Spectrum CARB-Type ß-Lactamase, RTG-4, from Acinetobacter baumannii

Acinetobacter baumannii isolate KAR was uncommonly more resistant to cefepime and cefpirome than to ceftazidime and cefotaxime. Cloning and expression of the β-lactamase gene content of this isolate into Escherichia coli TOP10 identified ß-lactamase RTG-4 (or CARB-10), which corresponds to the first...

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Bibliographic Details
Main Authors: Potron, Anaïs, Poirel, Laurent, Croizé, Jacques, Chanteperdrix, Vanessa, Nordmann, Patrice
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704689/
https://ncbi.nlm.nih.gov/pubmed/19380596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01164-08
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