Treatment with the Fusion Inhibitor Enfuvirtide Influences the Appearance of Mutations in the Human Immunodeficiency Virus Type 1 Regulatory Protein Rev

The gp41-encoding sequence of the env gene contains in two separate regions the Rev-responsive elements (RRE) and the alternative open reading frame of the second exon of the regulatory protein Rev. The binding of Rev to the RRE allows the transport of unspliced/singly spliced viral mRNAs out of the...

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Bibliographic Details
Main Authors: Svicher, Valentina, Alteri, Claudia, D'Arrigo, Roberta, Laganà, Alessandro, Trignetti, Maria, Lo Caputo, Sergio, Callegaro, Anna Paola, Maggiolo, Franco, Mazzotta, Francesco, Ferro, Alfredo, Dimonte, Salvatore, Aquaro, Stefano, di Perri, Giovanni, Bonora, Stefano, Tommasi, Chiara, Trotta, Maria Paola, Narciso, Pasquale, Antinori, Andrea, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704662/
https://ncbi.nlm.nih.gov/pubmed/19124665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01067-08
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